Effect of Several New and Currently Available Oxime Cholinesterase Reactivators on Tabun-intoxicated Rats
نویسندگان
چکیده
منابع مشابه
Effect of Several New and Currently Available Oxime Cholinesterase Reactivators on Tabun-intoxicated Rats
The therapeutical efficacies of eleven oxime-based acetylcholinesterase reactivators were compared in an in vivo (rat model) study of treatment of intoxication caused by tabun. In this group there were some currently available oximes (obidoxime, trimedoxime and HI-6) and the rest were newly synthesized compounds. The best reactivation efficacy for acetylcholinesterase in blood (expressed as per...
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Seven new oxime-based acetylcholinesterase reactivators were compared with three currently available ones (obidoxime, trimedoxime, HI-6) for their ability to lessen cholinesterase inhibition in blood and brain of cyclosarin-treated rats. Oximes were given at doses of 5% their LD(50) along with 21 mg/kg atropine five min before the LD(50) of cyclosarin (120 ug/kg) was administered. Blood and bra...
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The potency of newly developed bispyridinium compounds (K117, K127) to reduce tabun-induced acute neurotoxic signs and symptoms was compared with currently available oxime (obidoxime) using functional observational battery. The neuroprotective effects of atropine alone and atropine combined with one of three bispyridinium oximes (K117, K127, obidoxime) on rats poisoned with tabun at a sublethal...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2008
ISSN: 1422-0067
DOI: 10.3390/ijms9112243